Preparation of Alginate Hydrogel Supported by Hollow Silica Microspheres for Sustained-Release Application

Xiang-Hua Ling¹, Man-Ke Zhang¹,Hao-Yu Zhouand Guo-ZhiHan*

College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, 211816, P.R. China

Abstract:we develop a novel alginate hydrogel supported by hollow silica microsphere for drug delivery. Briefly, the drugs were fused with sodium alginate and the hollow silica microspheres follow by ion crosslinking to form a composite hydrogel microsphere with a core-shell structure (SA@SiO₂). On this basis, using three different types of organic compounds (rhodamine B, Indocyanine green and salicylic acid) as model molecules, the sustained-release performance of the SA@SiO₂microspheres were investigated in detail. The research results show that the drug delivery system has broad-spectrum sustained-release performance for different types of molecules, and the sustained-release time can exceed 40 hours. At the same time, the pH-responsiveproperty of the sodium alginate hydrogel endows the delivery system with a certain targeting function. This study provides a new strategy for constructing an efficient targeted drug sustained-release system.

European Polymer Journal,2024, 204,112716. (IF: 6.0)

论文链接：https://doi.org/10.1016/j.eurpolymj.2023.112716