Nickel-Catalyzed Direct Cross-Coupling of Aryl Thioether with Aryl Bromide

Na-Na Ma,^aXuan-Bo Hu,^aYuan-Shuai Wu,^aYa-Wen Zheng,^aMengtao Ma,^bXue-Qiang Chu,^aHao Xu,*^aHaiqing Luo,*^cand Zhi-Liang Shen*^a

^aTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.E-mail: xuhao@njtech.edu.cn; ias_zlshen@njtech.edu.cn.

^bCollege of Science, Nanjing Forestry University, Nanjing 210037, China.

^cDepartment of Chemistry & Chemical Engineering, Gannan Normal University, Ganzhou 341000, ChinaE-mail: luohaiq@sina.com.

Abstract:A straightforward cross-coupling of aryl thioether with aryl bromide with the aid of nickel salt, magnesium, and lithium chloride in tetrahydrofuran at ambient temperature was accomplished. The one-pot reactions proceeded efficiently via C−S bond cleavage to produce the desired biaryls in modest to good yields, avoiding the use of pregenerated or commercial organometallic reagents.

OrganicLetters2023,25, 1771-1775. (Impact factor: 5.2)

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.3c00518