Nickel-catalyzed direct cross-coupling of aryl fluorosulfateswith aryl bromides

Jin-He Na,^aXiang Liu,^aJia-Wen Jing,^aJing Wang,^bXue-Qiang Chu,^aMengtao Ma,^cHao Xu,*^aXiaocong Zhou,*^band Zhi-Liang Shen*^a

^aTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China. E-mail: xuhao@njtech.edu.cn; ias_zlshen@njtech.edu.cn.

^bCollege of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, China. E-mail: xczhou@zjxu.edu.cn.

^cCollege of Science, Nanjing Forestry University, Nanjing 210037, China.

Abstract:A one-pot,direct cross-coupling of aryl fluorosulfate with aryl bromide, which isstep-economicaland avoids the use of preprepared/commercial organometallic reagent, could beaccomplishedby performing the reactionin THFat room temperaturein the presence ofnickel catalyst,magnesium turnings, and lithium chloride, giving rise tothe corresponding biaryls in moderate to good yieldswith reasonable functional group compatibility.

Organic Letters2023,25,2318-2322. (Impact factor: 5.2)

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.3c00674